Fig. 3.

a Average pain intensity (NPRS 0–10 scores) before and within 12 weeks after single treatment with the capsaicin 179 mg patch in patients with CIPN-related pain (dark blue) and in the total study population (light blue; peripheral neuropathic pain of different etiologies). The absolute change between the mean NPRS scores at baseline and week 1–2 to week 12 was − 2.4 (0.4 SEM, p ≤ 0.001, paired t test) for CIPN patients and − 1.7 (0.1 SEM, p ≤ 0.001, paired t test) for the total QUEPP study population. NPRS = numeric pain rating scale; SEM = standard error of the mean. b Mean scores of intensity of sensory symptoms between baseline and the end of the observational period at week 12 in CIPN patients assessed with the painDETECT® questionnaire. For each symptom, single scores were assessed (never, 0; hardly noticed, 1; slightly, 2; moderately, 3; strongly, 4; very strongly, 5) at baseline and after 12 weeks. Relative changes of symptoms (%) are shown within the bars (mean, SEM). Baseline score > 0; SEM = standard error of the mean. Modified from [73]