Table 1.
Hazard ratio (HR) and corresponding confidence interval (CI) for loco-regional failure, progression, and death according to socio-demographic and clinical characteristics
| Patients | Locoregional failure | PFS | OS | ||
|---|---|---|---|---|---|
| n | (%) | HR (95% CI)a | HR (95% CI) | HR (95% CI) | |
| Gender | |||||
| Male | 151 | (67.7) | Reference | Reference | Reference |
| Female | 72 | (32.3) | 0.81 (0.32–2.05) | 0.77 (0.44–1.36) | 0.68 (0.36–1.29) |
| Age (years) | |||||
| < 65 | 89 | (39.9) | Reference | Reference | Reference |
| 65–74 | 52 | (23.3) | 0.72 (0.26–2.04) | 1.51 (0.78–2.92) | 2.09 (0.95–4.58) |
| ≥ 75 | 82 | (36.8) | 0.41 (0.15–1.15) | 1.24 (0.65–2.34) | 2.10 (1.00–4.42) |
| Educationb | |||||
| Low | 151 | (70.9) | Reference | Reference | Reference |
| High | 62 | (29.1) | 0.45 (0.17–1.20) | 0.46 (0.23–0.92) | 0.38 (0.16–0.90) |
| BMI (kg m−2) | |||||
| < 25 | 124 | (55.6) | Reference | Reference | Reference |
| ≥ 25 | 99 | (44.4) | 1.34 (0.56–3.19) | 0.93 (0.55–1.57) | 0.81 (0.44–1.48) |
| Smoking habitsc | |||||
| Never | 42 | (19.3) | Reference | Reference | Reference |
| Ever | 176 | (80.7) | 1.36 (0.38–4.82) | 1.12 (0.55–2.25) | 0.96 (0.45–2.02) |
| Drinking habitsd | |||||
| Never | 122 | (61.3) | Reference | Reference | Reference |
| Ever | 77 | (38.7) | 0.53 (0.21–1.33) | 0.73 (0.42–1.28) | 0.69 (0.36–1.30) |
| ACE-27 | |||||
| None-Mild | 101 | (45.3) | Reference | Reference | Reference |
| Moderate-Severe | 122 | (54.7) | 0.83 (0.30–2.35) | 1.17 (0.66–2.05) | 1.00 (0.53–1.89) |
| Cancer site | |||||
| Oral cavity | 109 | (47.4) | Reference | Reference | Reference |
| Oropharynx | 26 | (11.3) | 7.93 (2.47–25.50) | 2.01 (0.99–4.07) | 1.11 (0.47–2.60) |
| Hypopharynx/Larynx | 95 | (41.3) | 0.53 (0.14–2.08) | 1.01 (0.55–1.86) | 1.14 (0.59–2.21) |
| pT | |||||
| pT1-pT2 | 104 | (46.6) | Reference | Reference | Reference |
| pT3-pT4 | 119 | (53.4) | 0.51 (0.22–1.14) | 0.81 (0.46–1.41) | 1.11 (0.59–2.09) |
| pNe | |||||
| pN0 | 143 | (65.0) | Reference | Reference | Reference |
| pN1-pN3 | 77 | (35.0) | 1.34 (0.56–3.24) | 2.00 (0.16–3.44) | 2.35 (1.28–4.32) |
| Stage | |||||
| I–II | 90 | (36.3) | Reference | Reference | Reference |
| III–V | 158 | (63.7) | 0.54 (0.22–1.31) | 1.02 (0.58–1.79) | 1.35 (0.70–2.61) |
| Grading (differentiation) | |||||
| Well | 22 | (9.9) | Reference | Reference | Reference |
| Moderately | 155 | (69.5) | 1.32 (0.17–10.46) | 1.35 (0.41–4.49) | 1.52 (0.35–6.54) |
| Poorly | 46 | (20.6) | 1.72 (0.20–15.10) | 2.34 (0.65–8.45) | 2.30 (0.49–10.85) |
| Surgical margins | |||||
| Negative | 176 | (78.9) | Reference | Reference | Reference |
| Close/Positive | 47 | (21.1) | 2.45 (1.00–5.97) | 1.76 (0.99–3.12) | 1.96 (1.04–3.69) |
| Extracapsular extension | |||||
| Absent | 177 | (89.4) | Reference | Reference | Reference |
| Present | 21 | (10.6) | 1.27 (0.57–2.83) | 1.36 (0.63–2.93) | 1.14 (0.49–2.67) |
HRs and CIs were estimated from Cox proportional hazard model, adjusting for gender, age, education, pN, and surgical margins
aAdjusted for competing risks according to Fine-Gray model
bEducation level is missing in 10 patients
cSmoking habit is missing in five patients
dDrinking habit is missing in 24 patients
epN is missing in three patients