Table 2.
Hazard ratio (HR) and corresponding 95% confidence interval (CI) for local failure, regional failure, distant failure, progression, and death according to blood parameters
| Pts | Loco-regional failure | PFS | OS | |
|---|---|---|---|---|
| HR (95% CI)a | HR (95% CI) | HR (95% CI) | ||
| Hemoglobin (g/L) | ||||
| < 139 | 75 | Reference | Reference | Reference |
| 139–151 | 89 | 1.50 (0.55–4.08) | 0.75 (0.42–1.32) | 0.56 (0.29–1.08) |
| ≥ 152 | 59 | 0.80 (0.23–2.75) | 0.43 (0.20–0.95) | 0.41 (0.17–0.98) |
| Albumin (g/dL) | ||||
| < 4.0 | 75 | Reference | Reference | Reference |
| 4.0–4.3 | 74 | 0.80 (0.28–2.23) | 0.59 (0.31–1.10) | 0.59 (0.29–1.22) |
| ≥ 4.4 | 74 | 0.88 (0.34–2.31) | 0.49 (0.25–0.94) | 0.53 (0.25–1.09) |
| Neutrophils (103/μL) | ||||
| < 4.1 | 74 | Reference | Reference | Reference |
| 4.1–5.7 | 75 | 1.29 (0.38–4.32) | 1.30 (0.65–2.57) | 1.10 (0.52–2.34) |
| ≥ 5.8 | 74 | 0.98 (0.31–3.07) | 1.16 (0.58–2.33) | 1.05 (0.48–2.28) |
| Lymphocytes (103/μL) | ||||
| < 1.6 | 72 | Reference | Reference | Reference |
| 1.6–2.0 | 84 | 0.70 (0.24–2.06) | 0.73 (0.39–1.35) | 0.83 (0.42–1.63) |
| ≥ 2.1 | 67 | 1.25 (0.45–3.44) | 0.85 (0.43–1.67) | 1.80 (0.36–1.74) |
| Monocytes (103/μL) | ||||
| < 0.51 | 84 | Reference | Reference | Reference |
| 0.51–0.71 | 71 | 0.64 (0.19–2.20) | 0.93 (0.47–1.82) | 0.96 (0.46–1.98) |
| ≥ 0.72 | 68 | 1.13 (0.42–3.05) | 1.72 (0.91–3.26) | 1.66 (0.78–3.50) |
HRs and CIs were estimated from Cox proportional hazard model, adjusting for gender, age, education, pN, and surgical margins
aAdjusted for competing risks according to Fine-Gray model