Table 3.

Hazard ratio (HR) and corresponding 95% confidence interval (CI) for loco-regional failure, progression, and death according to inflammatory and nutritional indexes

	Pts	Locoregional failure	PFS	OS
		HR (95% CI)a	HR (95% CI)	HR (95% CI)
NLR
≥ 3.7	49	Reference	Reference	Reference
< 3.7	174	0.77 (0.30–1.96)	0.53 (0.30–0.92)	0.51 (0.28–0.96)
ALI
≥ 50.3	71	Reference	Reference	Reference
20.4–50.2	116	0.83 (0.30–2.32)	1.32 (0.66–2.66)	1.30 (0.58–2.91)
< 20.4	36	1.31 (0.40–4.27)	3.23 (1.51–6.90)	3.41 (1.47–7.91)
PNI
≥ 42.4	95	Reference	Reference	Reference
40.5–42.3	49	1.49 (0.48–4.62)	1.53 (0.74–3.16)	1.48 (0.64–3.41)
< 40.5	79	1.64 (0.65–4.11)	2.43 (1.31–4.51)	2.40 (1.19–4.82)
SIM
< 1.3	88	Reference	Reference	Reference
1.3–2.4	83	1.39 (0.44–4.44)	1.67 (0.86–3.27)	1.35 (0.65–2.83)
≥ 2.5	52	2.24 (0.73–6.90)	2.51 (1.23–5.10)	2.60 (1.19–5.67)

HRs and CIs were estimated from Cox proportional hazard model, adjusting for gender, age, education, pN, and surgical margins

^aAdjusted for competing risks according to Fine-Gray model