Table 1A.
Distributions of selected baseline variables and outcome variables (N = 210).
| Mean ± SE if continuous (Geometric Mean */ SE for Variables with Skewed Distributions) | |
|---|---|
| Baseline variable | Percentage with characteristic if categorical |
| DOT | |
| <2015 | 38.6% (81/210) |
| ≥2015 | 61.4% (129/210) |
| Recipient Age (yr) | 49.4 ± 1.1 (N = 210) (Median = 51.8, Range: 4–80) |
| Recipient age (yr) | |
| <18 | 3.3% (7/210) |
| ≥18, <50 | 42.4% (89/210) |
| ≥50 | 54.3% (114/210) |
| Recipient gender | |
| Female | 35.7% (75/210) |
| Male | 64.3% (135/210) |
| Recipient race/ethnicity | |
| Black (non-Hispanic) | 19.0% (40/210) |
| Hispanic | 36.2% (76/210) |
| White (non-Hispanic) | 42.4% (89/210) |
| Other | 2.4% (5/210) |
| Recipient BMI (kg/m2) | 26.4 ± 0.4 (N = 208) (Median = 26.2, Range: 13.9–42.4) |
| Recipient pretransplant diabetes mellitus | |
| No | 79.5% (167/210) |
| Yes | 20.5% (43/210) |
| Retransplant | |
| No | 96.7% (203/210) |
| Yes | 3.3% (7/210) |
| Donor type | |
| Living related | 53.8% (113/210) |
| Living unrelated | 46.2% (97/210) |
| Kidney | |
| Right | 10.0% (21/210) |
| Left | 90.0% (189/210) |
| Number of donor arteries | |
| 1 | 76.7% (161/210) |
| 2 | 19.5% (41/210) |
| 3 | 3.8% (8/210) |
| Number of donor veins | |
| 1 | 99.0% (208/210) |
| 2 | 1.0% (2/210) |
| Vascular reconstruction | |
| No | 73.3% (154/210) |
| Yes | 26.7% (56/210) |
| Double-J ureteral stent placed | |
| No | 91.4% (192/210) |
| Yes | 8.6% (18/210) |
| CIT (h) | 0.86 ± 0.03 (N = 209) (Median = 0.75, Range: 0.17–3.33) |
| WIT (min) | 30.40 */ 1.02 (N = 209) (Median = 28, Range: 16–117) |
| EBL (ml) | 36.2 */ 1.06 (N = 210) (Median = 30.0, Range: 10–780) |
| Operative Time (h) | 4.17 ± 0.08 (N = 210) (Median = 4.0, Range: 1.0–8.4) |
| Length of Hospital Stay (days) | 4.40 */ 1.03 (N = 210) (Median = 4, Range: 2–67) |
| Developed DGF | |
| No | 100.0% (210/210) |
| Yes | 0.0% (0/210) |
| Developed a post-operative (or surgical) complication within 30 days (12 months) post-transplanta | |
| No | 96.2% (202/210) |
| Yes | 3.8% (8/210) |
| Developed a urologic complication within 12 months post-transplanta | |
| No | 98.6% (207/210) |
| Yes | 1.4% (3/210) |
| eGFR at 3 mo post-tx (ml/min/1.73m2) | 77.1 ± 1.7 (N = 205) (Median = 73.0, Range: 32.5–206.7) |
| eGFR at 6 mo post-tx (ml/min/1.73m2) | 76.1 ± 1.8 (N = 200) (Median = 75.0, Range: 8.3–190.3) |
| eGFR at 12 mo post-tx (ml/min/1.73m2) | 75.5 ± 1.7 (N = 198) (Median = 73.2, Range: 15.6–174.8) |
| eGFR at 36 mo post-tx (ml/min/1.73m2) | 71.3 ± 2.3 (N = 93) (Median = 69.9, Range: 12.0–148.1) |
| eGFR at 60 mo post-tx (ml/min/1.73m2) | 64.9 ± 3.4 (N = 56) (Median = 68.3, Range: 6.2–113.8) |
| Graft failure (i.e., return to permanent dialysis or retransplanted) (as of the last follow-up date)b | |
| No | 97.1% (204/210) |
| Yes | 2.9% (6/210) |
| Death with a functioning graft (as of the last follow-up date)b | |
| No | 95.7% (201/210) |
| Yes | 4.3% (9/210) |
| Graft loss (death uncensored) (as of the last follow-up date)b | |
| No | 92.9% (195/210) |
| Yes | 7.1% (15/210) |
Among the eight patients who developed a post-operative (or surgical) complication during the first 30 days (12 months) post-transplant, the following complications were observed: acute respiratory distress syndrome (ARDS) (N = 1), wound infection (N = 1), wound infection/necrosis (N = 1), c. difficile colitis/sepsis (N = 1), diverticulitis (N = 1), bladder leak (N = 1), ureteral stricture (N = 1), and possible ureteral leak (N = 1).
The date of last follow-up for this study was March 20, 2020. Median follow-up among 195 patients who were alive with a functioning graft as of the last follow-up date was 26.2 (range: 12.0–128.4) months post-transplant. The six causes and times-to-graft failure (return to permanent dialysis) were as follows (listed chronologically by time to graft failure): acute AMR at 5.4 months, acute T-cell mediated rejection at 41.8 months, MPGN recurrence at 58.0 months, CAI at 67.7 months, CAI at 68.2 months, and acute AMR/non-adherence at 86.7 months post-transplant. The nine causes of death with a functioning graft and times-to-death were as follows: cardiovascular event in six patients (at 3.3, 5.2, 7.9, 12.9, 59.9, and 69.6 months post-transplant), and infection/sepsis in three patients (at 0.8, 12.2, and 17.4 months post-transplant).