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. 2021 Jun 28;16(3):519–530. doi: 10.1007/s11481-021-10001-y

9:30 am-

9:35 am

Welcome message

Dr. Sulie L. Chang, PhD, Professor of Biological Sciences and Director, Institute of Neuroimmune Pharmacology, Seton Hall University, South Orange, NJ, USA

9:35 am-

10:05 am

Special talks, 15 min each

Dr. Changhai Cui, PhD, Program Official, Division of Neuroscience and Behavior, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, MD, USA

Title: COVID-19 and funding opportunities from NIAAA

Dr. Yu (Woody) Lin, MD, PhD, Program Official, Integrative Neuroscience Branch (INB), Division of Neuroscience and Behavior (DNB), National Institute on Drug Abuse (NIDA), NIH, Bethesda, MD, USA

Title: COVID-19 and funding opportunities from NIDA

Symposium 1: Molecular approaches to COVID-19 pathogenesis and underlying mechanisms

Co-chairs: Dr. Changhai Cui, PhD, Program Official, NIAAA, NIH, Bethesda, MA, USA

Dr. Pankaj Seth, PhD, Professor and Scientist VII, National Brain Research Centre, Gurgaon, Haryana, India

10:10 am-

10:25 am

Speaker 1: Dr. Rosemarie Booze, PhD, Department of Psychology, University of South Carolina, Columbia, SC, USA

Title: Post-acute SARS-CoV-2 infection (PASC) in non-human primate olfactory system and pyriform cortex

10:25 am-

10:40 am

Speaker 2: Dr. Theodore Cory, PharmD, PhD, Department of Clinical Pharmacy and Translational Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA

Title: Cellular senescence alters fibrogenesis in SARS-CoV-2 infected macrophage/fibroblast co-cultures

10:40 am-

10.55 am

Speaker 3: Dr. Navneet Dhillon, PhD, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA

Title: Assessment of circulating extracellular vesicles reveals pro-inflammatory and thrombosis related protein cargo in COVID-19 patients

10:55 am-

11:10 am

Speaker 4: Dr. Howard Gendelman, MD, Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

Title: SARS-CoV-2 induction of a pro-inflammatory human macrophage

11:10 am-

11.25 am

Speaker 5: Dr. Supriya Mahajan, PhD, Department of Medicine, Division of Allergy, Immunology & Rheumatology

Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical Translational Research Center, Buffalo, NY, USA

Title: Mitochondrial dynamics in SARS-CoV-2 spike protein treated human microglia: Implications for Neuro-COVID

11:25 am-

11.40 am

Speaker 6: Dr. Servio Ramirez, PhD, Department of Pathology and Laboratory Medicine, Center for Substance Abuse Research, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

Title: The SARS-CoV-2 spike protein triggers brain endothelial activation and negatively affects the function of the blood–brain barrier; implications for neuroinvasive mechanisms of emerging coronaviruses

Symposium 2: Therapeutic/vaccine approaches to COVID-19

Co-chairs: Dr. Nazira El-Hage, PhD, Associate Professor, School of Medicine, Florida International University, Miami, USA

Dr. Yu (Woody) Lin, MD, PhD, Program Official, INB, DNB, NIDA, NIH, Bethesda, MD, USA

11:45 am-

12:00 pm

Speaker 1: Dr. Siddappa Byrareddy, PhD, Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

Title: Development of targeted therapeutics for COVID-19

12:00 pm-

12:15 pm

Speaker 2: Dr. Wen-Zhe Ho, MD, MPH, Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA

Title: Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor

12:15 pm-

12:30 pm

Speaker 3: Dr. Rafal Kaminski, PhD, Center for Neurovirology/Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

Title: Targeting N-glycosylation and palmitoylation pathways to block coronavirus infectivity

12:30 pm-

12:45 pm

Speaker 4: Dr. Bhavesh Kevadiya, PhD, Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

Title: Development of a layer-by-layer SARS-CoV-2 microparticle vaccine

12:45 pm-

1:00 pm

Speaker 5: Dr. Jag Khalsa, PhD, Formerly, Chief, Medical Consequences of Drug Abuse and Infections Branch, National Institute on Drug Abuse, NIH; Currently a Special Volunteer NIDA/NIH, Bethesda, MA, USA

Dr. Sanjay Maggirwar, PhD, Department of Microbiology, Immunology, and Tropical Medicine, The George Washington School of Medicine and Health Sciences, Washington, DC, USA

Dr. Gregory Bunt, MD, NYU and Samaritan Day Top Village Addiction Treatment Center, New York, NY, USA

Title: COVID-19, cannabis/CBD, and the physician

1:00 pm-

1.15 pm

Speaker 6: Dr. Kalipada Pahan, PhD, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA

Title: AIDS for COVID-19!

15-min break

Symposium 3: Early career investigators (pre- and post-doctorate fellows)

Co-chairs: Dr. Gurudutt Pendyala, PhD, Associate Professor, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

Dr. John Satterlee, PhD, Special Assistant to the DNB Director, Division of Neuroscience and Behavior (DNB), National Institute on Drug Abuse (NIDA), NIH, Bethesda, MD, USA

1:30 pm-

1:45 pm

Special talk: Dr. John Satterlee, PhD, Special Assistant to the DNB Director, DNB, NIDA, NIH, Bethesda, MD, USA

Title: Opportunities from NIH for ECI fellows

1:45 pm-

1:53 pm

Speaker 1: Dr. Arpan Acharya, PhD, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

Title: HIV-1/SARS-CoV-2 coinfection and CNS pathogenesis

1:53 pm-

2:01 pm

Speaker 2: Liana Basova, BA, San Diego Biomedical Research Institute, La Jolla, CA, USA

Title: Systems biology approaches detect early neuroinflammation and calcium signaling signatures in SARS-Cov-2 infection which are not affected by H1N1 in tracheal biopsies from the ferret model

2:01 pm-

2:09 pm

Speaker 3: Michael Mora Stangis, BA, Miller School of Medicine, University of Miami, FL, USA

Title: Methamphetamine potentiates the S1 subunit of SARS-CoV-2 spike protein-induced downregulation of tight junction proteins of human brain endothelial cells

2:09 pm-

2:17 pm

Speaker 4: Dr. Silvia Torices, PhD, Miller School of Medicine, University of Miami, FL, USA

Title: Expression of SARS-CoV-2-related receptors in naïve and HIV-1-infected cells of the neurovascular unit

2:17 pm-

2:25 pm

Panel discussion: Dr. Yisel Cantres-Rosario, PhD, Department of Microbiology and Medical Zoology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA

Symposium 4: Diversity and Inclusion SNIP Committee: Well-being and reflections

Co-chairs: Dr. Sowmya Yelamanchili, PhD, Assistant Professor, Department of Anesthesiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

Dr. Jeymohan Joseph, PhD, Chief, HIV Neuropathogenesis, Genetics and Therapeutics Branch (HNGTB), Division of AIDS Research (DAR), National Institute of Mental Health (NIMH), Bethesda, MD, USA

2:30 pm-

2:45 pm

Special talk: Dr. Jeymohan Joseph, PhD, Chief, HNGTB, DAR, NIMH, Bethesda, MD, USA

Title: Neurologic and psychiatric complications of SARS-CoV-2 infection

2:45 pm-

3:00 pm

Speaker 1: Dr. Thirumala-Devi Kanneganti, PhD, Immunology Department, St. Jude Children's Research Hospital, Memphis, TN, USA

Title: Targeting innate immunity and inflammatory cell death, PANoptosis, for the treatment of COVID-19

3:00 pm-

3:15 pm

Speaker 2: Dr. Santosh Kumar, PhD, Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA

Title: Intervention and improved well-being of basic science researchers during the COVID 19 era: a case study

3:15 pm-

3:55 pm

Panel discussion: Reflection and sharing

Panelists: Drs. Jean Bidlack, Sylvia Fitting, Santhi Gorantla, Cecilia Marcondes, Loyda Melendez, Ilker Sariyer

3:55 pm Conclusion