TABLE 6.

The closed-loop stimulation system for epilepsy.

Source	Platform	Clock (MHz)	Filter (Hz)	Feature
Avestruz et al. (2008)	N/A	N/A	0–500	Bandpower (15–40 Hz)
Halpern et al. (2009)	RNS	N/A	1–333	Bandpower (1–4, 4–8, 8–13, 13–25, and 20–50, > 50 Hz), total power, spike
Chen et al. (2011a)	FPGA	402	N/A	Bandpower (7–9 and 14–18 Hz) and ApEn
Chen et al. (2011b)	FPGA	402	0–3.2 k	Bandpower (7–9 Hz and harmonics) and ApEn
Young et al. (2011)	CC2430	32	0.8–72	Bandpower (7–9 and 14–18 Hz) and ApEn
Zanos et al. (2011)	Neurochip-2	N/A	0.5–5 k	Bandpower (10–20 Hz)
Chang et al. (2011)	CC2430	32	0.8–72	Bandpower (10–20 Hz)
Stanslaski et al. (2012)	Activa PC + S	N/A	0–250	Bandpower (beta band, ∼80 Hz)
Chen et al. (2014)	BSP	3.125	0.8–7 k	entropy and Bandpower (0.8–10 Hz)
Liu et al. (2014)	PennBMBI	N/A	300–6 k	Spike detection
Shoaran et al. (2015)	FPGA	N/A	30–1.7 k	Channel-based coastline features (linelength)
Do Valle et al. (2016)	N/A	8	0–500	Bandpower (0.5–4,:4–8,:8–13, and 13–30 Hz)
Irwin et al. (2016)	ATMega 328p	8	0.1–20 k	Bandpower (75–150 Hz)
Kassiri et al. (2017b)	GL060V5	10	10–5 k	Magnitude and Phase of FIR and Hilbert filter
Xie et al. (2017)	CC2541	32	0–7.5 k	Spike amplitude > 150 μV
Cheng et al. (2018)	BSP	N/A	0.59–117	Bandpower (7–9 and 14–18 Hz)
Hügle et al. (2018)	MSP430FR5994	8	N/A	Intrinsic mode functions
Pazhouhandeh et al. (2019)	N/A	10	0.5–10 k	Bandpower and heart rate
Lee et al. (2020)	MCU	2	0–150	ApEn and power (5, 10, and 15 Hz)

ApEn, approximate entropy; FIR, finite impulse response.