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The main pharmacokinetic parameters of rifaximin in mammary gland following an intramammary administration with single dose of 50, 100, 200, and 400 μg/gland in mice and analyzed by non-compartment model.
| Parameters | Administered dose (μg/gland) (n = 8) | ||||
|---|---|---|---|---|---|
| 50 | 100 | 200 | 400 | Mean ± SD | |
| Non-compartment model | |||||
| T1/2 (h) | 5.98 | 6.60 | 6.16 | 6.77 | 6.38 ± 0.37 |
| MRT (h) | 6.66 | 6.97 | 6.65 | 6.84 | 6.78 ± 0.15 |
| AUC24 (h·μg/g) | 176.83 | 373.35 | 602.01 | 1,215.86 | |
| Cmax (μg/g) | 25.82 | 45.32 | 80.52 | 165.23 | |
