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. 2021 Jun 14;14:697973. doi: 10.3389/fnmol.2021.697973

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Copyright © 2021 Nagano and Araki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathogenetic model of neurodegenerative diseases. Decrease in transport/translation of cytoskeleton-related mRNAs results in inhibiting maintenance of structural integrity of axons, especially of growth cone or synapses, leading neuronal dysfunction and degeneration. Decrease of transport/translation of translation-related (e.g., ribosomal protein mRNAs) mRNAs or many target mRNAs causes dysregulation of overall protein synthesis in axons, which leads neuronal dysfunction and degeneration.