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. 2021 Jun 14;11:671880. doi: 10.3389/fonc.2021.671880

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Copyright © 2021 Dittberner, Ziadat, Hoffmann, Pertzborn, Gassler and Guntinas-Lichius

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Head and neck squamous cell cancer of different subsites. Left row: White light endoscopy image. Middle row: Exemplary CLE image. Right row: Exemplary histopathology H&E image of the same tumor. (A–C) Tonsil cancer. (D–F) Same case as in A–C, now imaging and biopsy in the surrounding of the tonsil cancer. (G–I) Hypopharyngeal cancer. (J–L) Same case as in G–I, now imaging and biopsy in the surrounding of the hypopharyngeal cancer. (M–O) Another hypopharyngeal cancer. (P–R) Same case as in M–O, now imaging and biopsy in the surrounding of this hypopharyngeal cancer. CLE image size: 464 × 261 µm, 1,920 × 1,080 pixel. Histopathology: Hematoxylin & eosin staining, 10× magnification.