Table 2.
Comparison of outcomes between patients treated with high-flow nasal oxygen alone and those treated with non-invasive ventilation for post-extubation respiratory failure
| High-flow nasal oxygen (n = 62) | Non-invasive ventilation (n = 84) | Absolute difference, % (95% CI) | P value | |
|---|---|---|---|---|
| Primary outcome | ||||
| Mortality at day 28, n (%) | 18 (29%) | 15 (18%) | − 11 (− 25 to 2) | 0.11 |
| Secondary outcomes | ||||
| Reintubation at 48 h, n (%) | 32 (52%) | 37 (44%) | − 7 (− 23 to 9) | 0.37 |
| Reintubation up until ICU discharge, n (%) | 35 (56%) | 40 (48%) | − 9 (− 24 to 7) | 0.29 |
| Mortality of reintubated patients, n (%) | 11/35 (31%) | 12/40 (30%) | − 1 (− 22 to 19) | 0.89 |
| Interval between the onset of respiratory failure and reintubation, hours | 3.0 [1.3–10.5] | 5.1 [1.8–18.0] | – | 0.17 |
| Length of stay in ICU, days | 8 [4–14] | 8 [5–17] | – | 0.48 |
| Mortality in ICU, n (%) | 14 (23%) | 16 (19%) | − 4 (− 17 to 9) | 0.60 |
| Mortality at day 90, n (%) | 24 (39%) | 26 (31%) | − 8 (− 23 to 8) | 0.33 |
Continuous variables are given in mean ± standard deviation or median [interquartile range, IQR 25th–75th percentiles] according to their distribution