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. 2021 Jun 14;11:674286. doi: 10.3389/fonc.2021.674286

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Copyright © 2021 Pan, Bao, Zhang and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UBE2D3 interacted with SHP-2 and promoted its ubiquitination. (A) The protein and mRNA levels of SHP-2 in U87 and T98G cells transduced with specific shRNAs. (B) The protein and mRNA levels of SHP-2 in U251 cells with the overexpression of UBE2D3. (C) Co-immunoprecipitation assay using lysates of U87 cells confirmed the interaction between UBE2D3 and SHP-2. (D) The expression of SHP-2 in U251 cells with overexpressed UBE2D3 in the presence of 10 μM MG132 or Vehicle (DMSO). (E) The ubiquitination and expression level of SHP-2 after the transduction of shUBE2D3.