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. 2021 Jun 14;11:674286. doi: 10.3389/fonc.2021.674286

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Copyright © 2021 Pan, Bao, Zhang and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpressed SHP-2 reversed the effects of UBE2D3. (A) The expression of SHP-2 after transduced with SHP-2 overexpressed lentivirus in U251 cells with overexpressed UBE2D3 or not. (B, C) Cell proliferation (B) and apoptosis (C) of U251 cells with overexpressed SHP-2 and UBE2D3 or not. (D, E) Extracellular acidification rate (D), glycolytic capacity, glycolytic reserve (E) and oxygen consumption rate (F) of U251 cells with overexpressed SHP-2 and UBE2D3 or not. (G) Expression of HK-2, PFKL, STAT3, and p-STAT3 in U251 cells with overexpressed SHP-2 and UBE2D3 or not. *p < 0.05; **p < 0.01; ***p < 0.001.