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. 2021 Jun 14;9:698679. doi: 10.3389/fcell.2021.698679

FIGURE 2.

FIGURE 2

STING1 promotes erastin-induced ferroptosis with increased mitochondrial fusion. (A) Western blot analysis of STING1 expression in control and STINGKD PANC1 cells. (B–E) Indicated PANC1 cells were treated with erastin (10 μM, 24 h) or zalcitabine (20 μM, 72 h), and cell death, mitochondrial DNA damage, mtROS, and mitochondrial morphology were assayed (n = 3 wells/group; ANOVA with Tukey’s multiple comparisons test; *P < 0.05 versus control shRNA group; bar = 20 μm). Data are from two or three independent experiments.