Table 1.

Longitudinal multi-omic microbiome datasets and studies.

System	Sample type	Duration∗	Frequency∗	Total of samples	MG	MT	MP	MM	Complementary data	Studies
Human gut microbiome	Stool samples from 132 humans; healthy or with Crohn’s disease or ulcerative colitis	1 year	Bi-weekly	2,965	x	x	x	x	Host genomics, transcriptomics bisulfite sequencing, serologic profiles, diet surveys, and fecal calprotectin	Lloyd-Price et al., 2019
										Ruiz-Perez et al., 2021
	Stool samples of 77 individuals	6 months	Monthly	474	x			x	Host transcriptome, metabolome, cytokines, methylome, dietary survey, and physiology	Blasche et al., 2021
Activated sludge	Floating sludge islets from a single anoxic tank	1.5 year	Weekly	53	x	x	x	x	Temperature, pH, oxygen concentration, conductivity, inflow, nitrate concentration, and extracellular metabolites	Herold et al., 2020
										Martínez Arbas et al., 2021
	Full- and lab-scale activated sludge	2.5 months	Weekly	10	x	x			Temperature, pH, redox potential and dissolved oxygen	Law et al., 2016

Longitudinal multi-omic data must be of least six timepoints and at least two meta-omic readouts excluding 16S amplicon sequencing. Omics data derived from host(s) are considered separate from the microbial meta-omic spectra.

^∗Approximate values.