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. 2021 Jun 14;11:662444. doi: 10.3389/fonc.2021.662444

Figure 6.

Figure 6

Multiple siRNAs targeting different mouse-specific lncRNAs induce human colorectal tumor cells pyroptosis or apoptosis. Microscopic images of HCT116 and DLD1 cells transfected with siRNAs as indicated. Red arrowheads indicated the pyroptotic cells, and yellow arrowheads indicated the apoptosis cells. Scale bar, 100 μm. (A) Transfection with si-GM11815-1/2/3 induced HCT116 cells’ pyroptosis and apoptosis. (B) Transfection with si-BC026762-1/2 induced HCT116 cells’ pyroptosis and apoptosis, and transfection with si-BC026762-3 had no effect on HCT116 cells. (C) Transfection with si-GM15298-1/2/3 induced HCT116 cells’ pyroptosis and apoptosis. (D) Transfection with si-GM19792-1/2 induced HCT116 cells’ pyroptosis and apoptosis, and transfection with si-GM19792-3 had no effect on HCT116 cells. (E) Transfection with si-GM14951-1 had no effect on HCT116 cells, and transfection with si-GM14951-2/3 induced HCT116 cells’ pyroptosis and apoptosis. (F) Transfection with si-GM11851 and si-GM15758 had no effect on HCT116 cells. (G) Transfection with si-GM11815-1/2/3 induced DLD1 cells apoptosis. (H) Transfection with si-BC026762-1/2 induced DLD1 cells apoptosis and transfection with si-BC026762-3 had no effect on DLD1 cells. (I) Transfection with si-GM15298-1/2/3 inhibited the growth of DLD1 cells. (J) Transfection with si-GM19792-1/2/3 had no effect on DLD1 cells. (K) Transfection with si-GM14951-1/2/3 induced DLD1 cells apoptosis. (L) Transfection with si-GM11851 and si-GM15758 had no effect on DLD1 cells. Scale bar, 100 μm.