Table 4.
Diagnostic accuracy of DCE-MRI parameters of separate and combined mLVs-SSS for distinguishing I-ANMOSD patients from CNMOSD patients.
| AUROC | 95% CI | threshold | Sensitivity (%) | 95% CI | Specificity (%) | 95% CI | |
|---|---|---|---|---|---|---|---|
| TTP | |||||||
| L-mLVs-SSS | 0.9381 | 0.8572–1.0000 | 176.2 | 88.24 | 63.56–98.54 | 89.66 | 72.65–97.81 |
| R-mLVs-SSS | 0.9249 | 0.8402–1.0000 | 176.2 | 82.35 | 56.57–96.20 | 86.21 | 68.34–96.11 |
| Lo- mLVs-SSS | 0.7870 | 0.6581–0.9159 | 109.1 | 58.82 | 32.92–81.56 | 68.97 | 49.17–84.72 |
| L+R+Lo-mLVs-SSS | 0.9178 | 0.8315–1.0000 | 344.0 | 88.24 | 63.56–98.54 | 86.21 | 68.34–96.11 |
| L+R-mLVs-SSS | 0.9412 | 0.8613–1.0000 | 377.6 | 88.24 | 63.56–98.54 | 93.10 | 77.23–99.15 |
| L+ Lo-mLVs-SSS | 0.9057 | 0.8137–0.9977 | 293.7 | 88.24 | 63.56–98.54 | 86.21 | 68.34–96.11 |
| R+Lo-mLVs-SSS | 0.8844 | 0.7856–0.9831 | 276.9 | 82.35 | 56.57–96.20 | 79.31 | 60.28–92.01 |
| Wash in rate | |||||||
| L-mLVs-SSS | 0.6450 | 0.4838–0.8063 | 2.429 | 70.59 | 44.04–89.69 | 62.07 | 42.26–79.31 |
| R-mLVs-SSS | 0.5963 | 0.4308–0.7619 | 2.282 | 64.71 | 38.33–85.79 | 62.07 | 42.26–79.31 |
| Lo- mLVs-SSS | 0.7424 | 0.5994–0.8854 | 2.759 | 70.59 | 44.04–89.69 | 68.97 | 49.17–84.72 |
| L+R+Lo-mLVs-SSS | 0.7262 | 0.5759–0.8765 | 7.584 | 82.35 | 56.57–96.20 | 68.97 | 49.17–84.72 |
| L+R-mLVs-SSS | 0.6268 | 0.4648–0.7887 | 4.723 | 76.47 | 50.10–93.19 | 62.07 | 42.26–79.31 |
| L+ Lo-mLVs-SSS | 0.7525 | 0.6068– 0.8983 | 5.092 | 88.24 | 63.56–98.54 | 72.41 | 52.76–87.27 |
| R+Lo-mLVs-SSS | 0.7079 | 0.5549–0.8609 | 5.170 | 70.59 | 44.04–89.69 | 72.41 | 52.76–87.27 |
| AUC | |||||||
| L-mLVs-SSS | 0.9030 | 0.8303–0.9757 | 53644 | 70.59 | 44.04–89.69 | 79.31 | 60.28–92.01 |
| R-mLVs-SSS | 0.8093 | 0.6764–0.9422 | 47518 | 82.35 | 56.57–96.20 | 68.97 | 49.17–84.72 |
| Lo- mLVs-SSS | 0.8093 | 0.6793–0.9394 | 19853 | 82.35 | 56.57–96.20 | 65.52 | 45.67–82.06 |
| L+R+Lo-mLVs-SSS | 0.8458 | 0.7351–0.9566 | 125130 | 70.59 | 44.04–89.69 | 79.31 | 60.28–92.01 |
| L+R-mLVs-SSS | 0.8458 | 0.7336–0.9581 | 92146 | 82.35 | 56.57–96.20 | 68.97 | 49.17–84.72 |
| L+ Lo-mLVs-SSS | 0.8682 | 0.7636–0.9727 | 61531 | 88.24 | 63.56–98.54 | 68.97 | 49.17–84.72 |
| R+Lo-mLVs-SSS | 0.8134 | 0.6873–0.9395 | 62213 | 88.24 | 63.56–98.54 | 62.07 | 42.26–79.31 |
I-ANMOSD, neuromyelitis optica spectrum disorders patients with acute attack (EDSS ≤ 4.5); AUC, area under curve; AUROC, area under receiver operating characteristic curve; CI, confidence interval; CNMOSD, neuromyelitis optica spectrum disorders patients in chronic phase; L-mLVs-SSS, left meningeal lymphatic vessels around superior sagittal sinus; Lo-mLVs-SSS, lower meningeal lymphatic vessels around superior sagittal sinus; R-mLVs-SSS, right meningeal lymphatic vessels around superior sagittal sinus; TTP, time to peak.