Table 2.
Univariate and multivariate Cox regression analyses of OS in the TCGA training and internal validation cohorts of HNSCC.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| TCGA training cohort | ||||
| Age | 1.033 (1.015−1.051) | <0.001 | 1.031 (1.012−1.051) | 0.002 |
| Gender | 0.622 (0.423−0.914) | 0.016 | 0.833 (0.548−1.266) | 0.393 |
| Grade | 0.985 (0.731−1.328) | 0.923 | 1.081 (0.797−1.467) | 0.617 |
| Stage | 1.326 (1.050−1.674) | 0.018 | 1.681 (1.237−2.283) | <0.001 |
| T | 1.025 (0.843−1.247) | 0.803 | 0.801 (0.635−1.009) | 0.06 |
| N | 1.055 (0.851−1.306) | 0.626 | 1.052 (0.830−1.334) | 0.674 |
| Risk score | 6.945 (3.538−13.632) | <0.001 | 6.387 (3.281−12.432) | <0.001 |
| TCGA validation cohort | ||||
| Age | 1.007 (0.980−1.034) | 0.622 | 1.004 (0.975−1.035) | 0.785 |
| Gender | 1.855 (0.823−4.181) | 0.136 | 1.589 (0.684−3.690) | 0.281 |
| Grade | 1.353 (0.877−2.090) | 0.172 | 1.151 (0.725−1.826) | 0.551 |
| Stage | 1.198 (0.850−1.690) | 0.302 | 1.170 (0.684−2.002) | 0.566 |
| T | 1.123 (0.811−1.555) | 0.484 | 0.999 (0.628−1.591) | 0.997 |
| N | 1.066 (0.774−1.470) | 0.694 | 0.964 (0.647−1.436) | 0.856 |
| Risk score | 3.217 (1.691−6.118) | <0.001 | 2.812 (1.439−5.495) | 0.002 |
HR, Hazard ratio. Bold value showed significance.