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. 2021 Jun 14;12:621153. doi: 10.3389/fimmu.2021.621153

Figure 2.

Figure 2

(A) Representative pMHC-I and pMHC-II structures of different species. PDB accession numbers are between brackets. The top row shows side views, with the MHC molecules in cartoon format and the peptide in spheres format. The bottom row shows top views, in surface format. (B) Cladogram showing the phylogeny of the species shown in (A) (47, 48). Because in Agnatha no MHC genes are found and all classes of Gnathostomata possess both classical MHC-I and MHC-II, it can be assumed that MHC genes emerged and differentiated into classical MHC-I and MHC-II in the period highlighted by the blue bar. MYA, million years ago.