Table 3.
IC50 values of three key herbs for preparing Jingyin granules with strong CYP3A inhibition activities.
| Herbs | Extraction rate (%) | Time-dependent inhibitiona IC50 (μg/mL) | Ratio | |
|---|---|---|---|---|
| Preincubation for 3 min | Preincubation for 33 min | |||
| Radix Glycyrrhizae | 31.1 | 211.2 ± 19.9 | 101.8 ± 7.8 | 2.07 |
| Folium Llicis Purpureae | 29.4 | 419.8 ± 42.0 | 209.2 ± 8.1 | 2.01 |
| Herba Schizonepetae oil | 0.005952 mL/g | 267.7 ± 19.7 | 346.6 ± 57.8 | 0.77 |
aThe IC50 values were determined in HLMs following short (3 min) or long (33 min) preincubation time in the NADPH-generating system.