Skip to main content
. Author manuscript; available in PMC: 2021 Jun 28.
Published in final edited form as: Nat Cell Biol. 2020 Apr 13;22(5):591–602. doi: 10.1038/s41556-020-0495-y

Extended Data Fig. 10 ∣. High expression of ELF5/FBXW7 and low expression of IFNGR1 is protective in Mesenchymal, basal and immunomodulatory TNBC.

Extended Data Fig. 10 ∣

a-d, High expression of ELF5/FBXW7 and low expression of IFNGR1 is correlated with better Distant metastasis free survival (DMFS) in (a) Basal (n=24 for Elf5/FBXW7 and (n=32 for IFNGR1) (b) Immunomodulatory (n=47 patient samples for Elf5/FBXW7 and (n=36 patient samples for IFNGR1) (c) Mesenchymal TNBC subsets (n=57 for Elf5/FBXW7 and (n=57 patient samples for IFNGR1). (d) High expression of ELF5/FBXW7 and low expression of IFNGR1 is correlated with worse Distant metastasis free survival (DMFS) in Non-TNBC ER+ patients (n=437 patient samples for Elf5/FBXW7 and (n=1391 patient samples for IFNGR1). P-value was computed by Log Rank test. KM plotter database was used57. e, TNBC PDXs showing direct correlation between ELF5 and FBXW7, and indirect correlation with IFNGR1. 5 TNBC PDXs were used for this experiment. Two-tailed Mann-Whitney U test was used for statistical analysis and data is represented as mean ± SEM. (f-h) IHC images of TNBC PDXs showing direct correlation between ELF5 and FBXW7, and indirect correlation with IFNGR1. Scale bar, 40 μm.