Table 2.

Comparison of the Seven Differentially Expressed miRNAs In Our Study and Previously Published miRNA Studies on Glaucoma

Technique	Our Study Small RNA-Seq	Liu et al.14 Small RNA-Seq	Tanaka et al.15 3D-Gene Human miRNA ver.1.60 chip (2019 miRNAs)	Jayaram et al.16 2 TaqMan Low-Density Human MicroRNA Arrays(754 miRNAs)	Drewry et al.17 NanoString nCounterHuman v3 miRNA Expression Assay(800 miRNAs)	Hindle et al.18 Custom miR-Finder Array(372 miRNAs)
Sample size (C vs. G)	9 vs. 9	6 vs. 6	10 vs. 10	8 vs. 6	11 vs. 12	31 vs. 17
Glaucoma type	POAG no comorbidity	POAG no comorbidity	POAG, PACG, PEX	POAG with comorbidities	POAG (perhaps NTG)	POAG, PEX
Detected miRNAs	262	>426	530.5 ± 44.6	338	298	239
Significant miRNAs	7 (of 62)	88	29	3	3	6 (of 20)
hsa-mir-30a-3p	↑	Unknown	NS	NS	N/A	NS
hsa-mir-143-3p	↑	Unknown	N/A	↑	N/A	NS
hsa-miR-221-3p	↑	↑	N/A	N/A	N/A	N/A
hsa-mir-211-5p	↑	Unknown	NS	NS	NS	N/A
hsa-mir-486-5p	↓	NS	N/A	N/A	N/A	N/A
hsa-mir-451a	↓	Unknown	NS	NS	↑	NS
hsa-mir-92a-3p	↓	Unknown	NS	NS	N/A	N/A

Studies are indicated by name of the first author. Unknown indicates that we are uncertain whether the miRNA was detected in the study (if it was, it was not significant), because the authors did not disclose the full list of miRNAs identified.

C, control; G, glaucoma; ↑, significantly upregulated; ↓, significantly downregulated; N/A, not available for detection in the array; NS, detected in study but not significant.