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. Author manuscript; available in PMC: 2021 Jun 28.
Published in final edited form as: Nat Genet. 2021 Feb 8;53(3):342–353. doi: 10.1038/s41588-020-00774-y

Fig. 3. Landscape of protein-protein interaction-perturbing mutations across 33 cancer types.

Fig. 3.

The circos plot displays significant mutation perturbed protein-protein interactions (termed putative oncoPPIs, see Online Methods) which harbor a statistically significant excess number of missense mutations at PPI interfaces across 33 cancer types. The putative oncoPPIs with various significance levels (see Online Methods) are plotted in three inner layers. The links (edges, orange) connecting two oncoPPIs indicate two cancer types share the same oncoPPIs. Some significant oncoPPIs and their related mutations are plotted on the outer surface. The length of each line is proportional to −log10(P). All oncoPPIs and PPI-perturbing mutations are free available at https://mutanome.lerner.ccf.org/.