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. 2021 Mar 31;9(3):283–290. doi: 10.14218/JCTH.2020.00142

Fig. 6. Compared with HCs, the CD8+ T lymphocytes in peripheral blood from patients with HBV- ACLF were in an immune paralysis state.

Fig. 6

The cell viability (CD69) of ACLF patients (MFI: 1,723±143) was weaker than that of HCs (MFI: 3,017±132, p<0.001). The proliferative ability (Ki67) of ACLF (MFI: 1,737±139) was weakened compared with that of HCs (MFI: 2,603±173, p<0.001). Compared with HCs, the levels of secreted IL-2 (MFI: 330,067±10,033 vs. 150,587±9,157, p<0.001), IFN-γ (MFI: 2,423±116 vs. 1,737±161, p<0.001) and TNF-α (MFI: 10,948 ±819 vs. 4,050±242, p<0.001) were decreased in the ACLF group. ACLF, acute-on-chronic liver failure; HBV- ACLF, hepatitis B virus infection-induced acute-on-chronic liver failure; HCs, healthy controls; IFN-γ, interferon-gamma; MFI, mean fluorescence intensity; TNF-α, tumor necrosis factor-alpha.