Table 3. Incidences of PHLF of high-risk and low-risk groups with a cut-off value of 14.7 by the PHLF score in development and two validation cohorts.
| Development cohort, n=344 |
Internal validation cohort, n=148 |
External validation cohort, n=167 |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| High-risk group, n=126 | Low-risk group, n=218 | p-value | High-risk group, n=47 | Low-risk group, n=101 | p-value | High-risk group, n=71 | Low-risk group, n=96 | p-value | |
| PHLF† | <0.001 | <0.001 | 0.013 | ||||||
| No | 56 (44.4%) | 197 (90.4%) | 27 (57.4%) | 88 (87.1%) | 59 (83.1%) | 91 (94.8%) | |||
| Yes | 70 (55.6%) | 21 (9.6%) | 20 (42.6%) | 13 (12.9%) | 12 (16.9%) | 5 (5.2%) | |||
| PHLF grade† | <0.001 | <0.001 | 0.015 | ||||||
| 0 | 56 (44.4%) | 197 (90.4%) | 27 (57.4%) | 88 (87.1%) | 59 (83.1%) | 91 (94.8%) | |||
| A | 48 (38.1%) | 15 (6.9%) | 12 (25.5%) | 12 (11.9%) | 9 (12.7%) | 3 (3.1%) | |||
| B | 15 (11.9%) | 4 (1.8%) | 7 (14.9%) | 1 (1.0%) | 1 (1.4%) | 2 (2.1%) | |||
| C | 7 (5.6%) | 2 (0.9%) | 1 (2.1%) | 0 (0%) | 2 (2.8%) | 0 (0%) | |||
†PHLF was defined as postoperative deterioration of liver function with an increase in the INR and concomitant hyperbilirubinemia on or after postoperative day 5 as proposed by the ISGLS. ‡Following the ISGLS definition of PHLF grade.