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. 2021 Mar 19;80(7):865–875. doi: 10.1136/annrheumdis-2020-219012

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Experimental design and (B) data analysis procedures. Detailed methods are included in online supplemental materials. AUC-24h, area under the curve 0–24 hours; BARI, baricitinib; FIL, filgotinib; FSC-A, forward scatter area; HD, healthy donors; IC₅₀, half maximum inhibitory concentration; IL, interleukin; JAK, Janus kinase; JAKi, JAK inhibitor; MET, major metabolite of filgotinib (GS-829845); mono, monocytes; PBMCs, peripheral blood mononuclear cells; pSTAT, phosphorylated signal transducer and activator of transcription; RA, rheumatoid arthritis; SSC-A, side scatter area;TOFA, tofacitinib; UPA, upadacitinib.