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. 2021 Mar 19;80(7):865–875. doi: 10.1136/annrheumdis-2020-219012

Figure 6.

Figure 6

Calculated cytokine inhibition of JAK-STAT signalling pathways at clinical doses with similar efficacy. (A) Calculated average target inhibition (AUC-24h±SD) over a 24-hour dose interval for selected JAKinibs for a given stimuli/cell type/pSTAT based on in vitro measurements in whole blood from healthy donors (n=7–10). *P<0.05 higher vs FIL 200 mg; †P<0.05 lower vs FIL 200 mg. (B–F) Calculated average target inhibition (AUC-24h±SD) over a 24-hour dose interval for selected JAKinibs at clinical doses with similar efficacy for a given stimulus/cell type/pSTAT based on in vitro measurements in whole blood from healthy donors (n=7–10). The clinical doses represented were FIL (200 mg), TOFA (5 mg), UPA (15 mg) and BARI (4 mg). (B) JAK1/TYK2, (C) JAK1/JAK2, (D) JAK1/JAK3, (E) JAK2/TYK2 and (F) JAK2/JAK2; FIL includes contribution of GS-829845. Dashed lines show 50% target inhibition. *P<0.05, **P<0.01, ***P<0.001 vs FIL (200 mg). AUC-24h, area under the curve 0–24 hours; BARI, baricitinib; FIL, filgotinib; G-CSF, granulocyte-colony stimulating factor; GM-CSF, granulocyte macrophage colony stimulating factor; IFN, interferon; IL, interleukin; JAK, Janus kinase; JAKinib, JAK inhibitor; mono, monocyte; neut, neutrophil; NK, natural killer; pSTAT, phosphorylated signal transducer and activator of transcription; TOFA, tofacitinib; TYK2, tyrosine kinase 2; UPA, upadacitinib.