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. 2021 Jan 27;80(7):848–858. doi: 10.1136/annrheumdis-2020-219214

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Proportions of patients achieving (A) low disease activity and (B) DAS28(CRP) <2.6 or remission at weeks 12, 24 and 52. Error bars show 95% CI. Additional statistical details are available in online supplemental table S3. *p<0.05, **p<0.01, ***p<0.001 versus placebo, not adjusted for multiplicity and should be considered exploratory except for FIL200 and FIL100 versus placebo for DAS28(CRP) <2.6 at week 12. ^#Non-inferior versus adalimumab. ⁺p<0.05, ⁺⁺p<0.01, ⁺⁺⁺p<0.001 versus ADA, not adjusted for multiplicity and should be considered exploratory. ADA, adalimumab; Boolean, Boolean remission; CDAI, Clinical Disease Activity Index; DAS28(CRP), Disease Activity Score in 28 joints with C reactive protein; FIL100, filgotinib 100 mg; FIL200, filgotinib 200 mg; PBO, placebo; SDAI, Simplified Disease Activity Index.