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. 2021 Jun 14;12:696729. doi: 10.3389/fphar.2021.696729

FIGURE 4.

FIGURE 4

FRE suppresses the Mrgpr- and IgE/FcεRI-mediated MC degranulation in vivo. (A) Effect of FRE on the rectal temperature of C48/80-treated mice. Mice were i.p. injected C48/80 (4 mg/kg) 5 min before FRE administration (i.p.). Thirty minutes after C48/80 treatment, the rectal temperature was measured. ## p < 0.01 vs. control and **p < 0.01 vs. C48/80 alone group. (B) Effect of FRE on the rectal temperature of PSA mice. The sensitized mice were pretreated with FRE (i.p.) for 30 min and then i.v. challenged with SP (200 μg/mouse). The rectal temperature was monitored 20 min later. ## p < 0.01 vs. control and **p < 0.01 vs. SP alone group.