Bacterial species/group	Common infections	Antibiotics used	Relevant resistance tested
STAPHYLOCOCCI S. aureus S. pseudintermedius S. schleiferi	Skin infections Otitis Skin and soft tissue infections	First choice (Hillier et al., 2014): Clindamycin or lincomycin Amoxicillin clav 1G cephalosporins Sulfa/TMP Second choice Second choice (Hillier et al., 2014): Doxycycline 3G cephalosporins Fluoroquinolones First choice (topical) (Jessen et al., 2019): Fusidic acid Second choice (topical) (Jessen et al., 2019): Gentamicin Fluoroquinolones First choice (prophylaxis) (Jessen et al., 2019): Cefazolin	Clindamycin/lincomycin Methicillin Methicillin Sulfa/TMP Doxycycline/tetracycline Methicillin Enrofloxacin/ciprofloxacin Fusidic acid Gentamicin Enrofloxacin or ciprofloxacin Methicillin
ENTEROBACTERIACEAE Escherichia coli Klebsiella pneumoniaeProteus mirabilis Enterobacter spp.	Urinary tract infections Pyometra Bacteraemia	First choice (Jessen et al., 2019; Weese et al., 2019) Amoxicillin Amoxicillin clav Sulfa/TMP Second choice (Jessen et al., 2019; Weese et al., 2019): Fluoroquinolones Nitrofurantoin 3GCs First choice (Jessen et al., 2019): Fluoroquinolones Second choice (Jessen et al., 2019): Amoxicillin clav First choice (Jessen et al., 2019): Fluoroquinolone + ampicillin	Ampicillin/amoxicillin Amoxicillin clav Sulfa/TMP Enrofloxacin/ciprofloxacin Nitrofurantoin Cefpodoxime, cefotaxime, ceftazidime or ceftriaxone Enrofloxacin or ciprofloxacin Amoxicillin clav Enrofloxacin/ciprofloxacin Ampicillin/amoxicillin
PSEUDOMONAS P. aeruginosa	Otitis Wound infections	First choice (Jessen et al., 2019): Polymyxin Second choice (Jessen et al., 2019): Fluoroquinolones Gentamicin	Polymyxin/colistin Enrofloxacin/ciprofloxacin Gentamicin
ENTEROCOCCI E. faecalis E. faecium	Urinary tract infections Bacteraemia	First choice (Weese et al., 2019): Amoxicillin First choice (Jessen et al., 2019): Ampicillin + fluoroquinolone	Ampicillin/amoxicillin Sulfa/TMP Enrofloxacin/ciprofloxacin Ampicillin/amoxicillin Enrofloxacin/ciprofloxacin
CLOSTRIDIA C. difficile C. perfringens	Acute diarrhoea	First choice (Jessen et al., 2019): Amoxicillin Second choice: Metronidazole	Ampicillin/amoxicillin Metronidaxole