Table 2.
Effect of SARS-CoV-2 RBD variants (with lower RBD-ACE2 binding free energy than WT) on protein function.
| Viral variant | PredictSNP | MAPP | PhD-SNP | PolyPhen-1 | PolyPhen-2 | SIFT | SNAP |
|---|---|---|---|---|---|---|---|
| N501I | Neutral | Deleterious | Neutral | Neutral | Neutral | Neutral | Deleterious |
| N501S | Neutral | Neutral | Neutral | Deleterious | Neutral | Neutral | Neutral |
| N501T | Neutral | Neutral | Neutral | Neutral | Neutral | Neutral | Neutral |
| N501Y | Neutral | Neutral | Neutral | Neutral | Neutral | Deleterious | Deleterious |
| Y495F | Deleterious | Deleterious | Neutral | Neutral | Deleterious | Deleterious | Deleterious |
| Q493L | Neutral | Neutral | Neutral | Neutral | Neutral | Neutral | Deleterious |
| Q493H | Neutral | Neutral | Neutral | Neutral | Neutral | Neutral | Deleterious |
| A475V | Neutral | Deleterious | Neutral | Neutral | Neutral | Deleterious | Deleterious |
| L455F | Neutral | Neutral | Neutral | Neutral | Neutral | Neutral | Deleterious |
| Y453F | Neutral | Deleterious | Neutral | Neutral | Neutral | Neutral | Deleterious |
| G446S | Neutral | Neutral | Neutral | Neutral | Deleterious | Neutral | Deleterious |
| G446V | Deleterious | Deleterious | Deleterious | Neutral | Deleterious | Neutral | Deleterious |
| K417R | Neutral | Deleterious | Neutral | Neutral | Neutral | Deleterious | Neutral |