Penetrance dot colors (within light blue layer) reflect ancestry: blue = European, red = AA, green = Hispanic. AJ individuals are included as European-ancestry. Penetrance points plotted if TotalHet # > 10, HetCases > 1, and penetrance > 1. Max penetrance values for the light blue layer: Eur = 21.43, Afr = 10.53, His = 9.09. White layer = GERP scores > 3 and green layer = CADD scores > 10. Outer ticks represent 100kb in gene region.