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HDACi 1−14 and their in vitro activity and selectivity profiles. (a) Chemical structures of HDACi 1–14. (b) Biochemical HDAC inhibition against recombinant enzymes (Nanosyn) and cellular cytotoxicity results in MV4-11 (AML) and MRC-9 (healthy fibroblasts). Note: **not HDAC6 selective, *selectivity ≥ indicated value (beyond limit of experiment). A color gradient is applied for visualization of differential HDAC6 activity.
