Figure 5.

Sulfonamide-benzaldehydes are active in FA compound titrations. (A) 3D and 2D chemical structure of 4-formyl-benzenesulfonamide with a C–C–S–N torsion angle τ as indicated.⁴⁰ (B) The benzenesulfonamides are extended toward the FC pocket or toward the p65 peptide (red; 14-3-3: white; both with sticks and transparent surface) (PDB: 6YOW).²⁵ (C) FA compound titrations in the presence of 50 μM 14-3-3γ and 100 nM p65_45. The compounds are divided into weak (left), medium (middle), and high (right) activity. The legends are sorted by activity.