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IL-6/STAT3 signaling pathway affects the transcription of CLDN1 and CLDN2 via H3K27ac. (A) Expression of H3K27ac in NCM640 cells as determined by western blotting. (B and C) Enrichment of H3K27ac in the promoter regions of (B) CLDN1 and (C) CLDN2 as determined by chromatin immunoprecipitation-quantitative PCR. *P<0.05 vs. NC group; #P<0.05 vs. IL-6 group. CLDN, claudin; NC, negative control.
