Table 2.
Inhibition rate (%) by l-menthol of binding of a ligand against a specific molecule. This table shows a list of ligands of which inhibition rate were more than 1 % and less than 10 %.
| Molecule of interest | Radioactive isotope-labelled ligand | Preparation containing molecule of interest | Inhibition by l-Menthol (%) | Inhibition by a positive substance (%) | Positive substance |
|---|---|---|---|---|---|
|
10% > Inhibition >1 % | |||||
| Cannabinoid CB1 receptor (Human) | [3H]-CP-55,940 | Human recombinant | 9.12 | 100 | (R)-(+)-WIN55212-2 mesylate salt |
| Cannabinoid CB2 receptor (Human) | [3H]-CP-55,940 | Human recombinant | 8.57 | 100 | (R)-(+)-WIN55212-2 mesylate salt |
| Serotonin 5HT2A receptor (Human) | [3H]-Ketanserin hydrochloride | Human recombinant | 8.32 | 100 | Ketanserin tartrate salt |
| Adenosine A3 receptor (Human) | [125I]-AB-MECA | Human recombinant | 8.22 | 99.41 | IB-MECA |
| Norepinephrine transporter (Human) | [3H]-Nisoxetine hydrochloride | Human recombinant | 7.89 | 99.13 | Desipramine hydrochloride |
| Bradykinin B2 receptor (Human) | [3H]-Bradykinin | Human recombinant | 7.88 | 94.95 | HOE140 |
| α2C-Adrenergic receptor (Human) | [3H]-Rauwolscine hydrochloride | Human recombinant | 7.75 | 100 | Rauwolscine hydrochloride |
| Monoamine transporter | [3H]-α-Dihydrotetrabenazine | Rabbit platelet | 7.73 | 100 | Ketanserin tartrate salt |
| Imidazoline receptor (Central) | [3H]RX 781094(3H-Idazoxan) | Rat cerebral cortex | 6.53 | 100 | Guanabenz acetate salt |
| Dopamine D3 receptor (Human) | R-(+)-7-Hydroxy-[3H]DPAT | Human recombinant | 6.32 | 100 | (±)-7-Hydroxy-2-(di-n-propylamino)tetralin ((±)-7-OH-DPAT) |
| Neurokinin NK2 receptor (Human) | [3H]-SR 48968 | Human recombinant | 6.12 | 99.61 | Neurokinin A |
| Bradykinin B1 receptor (Human) | [3H]-Kallidin (Des-Arg 10, Leu 9) | Human recombinant | 6.03 | 100 | Lys-(des-Arg 9，Leu 8)-Bradykinin trifluoroacetate salt |
| Opiate ORL1 receptor (Human) | [3H]-Nociceptin | Human recombinant | 5.76 | 100 | Orphanin FQ |
| Melatonin MT1 receptor (Human) | [125I]-Melatonin | Human recombinant | 5.74 | 100 | Melatonin |
| α1A-Adrenergic receptor | [3H]-Prazosin | Rat submandibular gland | 5.13 | 100 | Prazosin hydrochloride |
| K channel KA | [125I]-Dendrotoxin | Rat cerebral cortex | 5.11 | 99.78 | α-Dendrotoxin |
| Opiate κ receptor (Human) | [3H]-Diprenorphine | Human recombinant | 4.86 | 100 | U-69593 |
| Neurokinin NK3 receptor (Human) | [125I]-Neurokinin B (N–Me-Phe 7) | Human recombinant | 4.65 | 100 | Succinyl-[Asp 6, N–Me-Phe 8]-Substance P Fragment 6–11(Senktide) |
| Glutamate (NMDA polyamine site) | [3H]-Ifenprodil | Rat cerebral cortex | 3.79 | 99.68 | Ifenprodil tartrate salt |
| Neurokinin NK1 receptor (Human) | [125I]-Substance P | Human recombinant | 3.74 | 99.87 | L-703,606 oxalate salt hydrate |
| Endothelin ETB receptor (Human) | [125I]-Endothelin-1 (Human, Porcine) | Human recombinant | 3.39 | 95.1 | Endothelin-1(Human) |
| CCK B receptor (Human) | [125I]-Cholecystokinin Octapeptide | Human recombinant | 3.31 | 100 | CCK-Octapeptide (26–33) (Sulfated Form) (CCK-8) |
| α2B-Adrenergic receptor (Human) | [3H]-Rauwolscine hydrochloride | Human recombinant | 2.87 | 100 | Rauwolscine hydrochloride |
| Glutamate receptor (NMDAglycine site) | [3H]-MDL105,519 | Rat cerebral cortex | 2.56 | 100 | MDL105,519 |
| VIP 1 receptor (Human) | [125I]-Vasoactive Intestinal Polypeptide | Human receptor (Non-recombinant) | 2.48 | 100 | Vasoactive Intestinal Peptide human, porcine, rat (VIP) |
| K Channel SkCa | [125I]-Apamin | Rat whole brain | 2.36 | 100 | Apamin |
| Serotonin 5HT3 receptor (Human) | [3H]-GR65630 | Human recombinant | 2.21 | 95.14 | MDL72222 |
| K Channel KATP | [3H]-Glybenclamide | Rat whole brain | 2.08 | 100 | Glibenclamide |
| Adenosine A1 receptor (Human) | [3H]8-Cyclopentyl-1,3-dipropylxanthine ([3H]-DPCPX) | Human recombinant | 1.83 | 96.61 | 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) |
| α1B-Adrenergic receptor | [3H]-Prazosin | Rat liver | 1.76 | 100 | Prazosin hydrochloride |
| GABA A receptor (Benzodiazepine site) | [3H]-Flunitrazepam | Rat whole brain | 1.37 | 100 | Diazepam |
| Glutamate receptor (NMDA phencycidine site) | [3H]-(+)-MK-801 | Rat cerebral cortex | 1.27 | 100 | (+)-MK-801 hydrogen maleate |
| Ca Channel (Type L, Dihydropyridine) | [3H]-PN200-110 | Rat cerebral cortex | 1.17 | 100 | Nitrendipine |
| GABA B receptor | gamma-[3H]-Aminobutyric Acid, ([3H]GABA) | Rat cerebellum | 1.1 | 93.92 | γ-Aminobutyric acid (GABA) |