Table 2.
Liver and serum parameters in normal chow diet (NCD) with a control shRNA (control-NCD) and western diet with 15% fructose in the drinking water (WDF) with a control shRNA (control-WDF) compared to Dio1 liver-specific knockdown (Dio1LKD-WDF). Significance is shown for WDF control vs. WDF Dio1 LKD. ∗p < 0.05, ∗∗p < 0.01. Data is depicted in mean ± SEM.
| Control-NCD | Control-WDF | Dio1LKD-WDF | |
|---|---|---|---|
| T4 liver (pmol/g) | 41.40 (4.71) | 28.12 (2.40) | 40.59 (2.81)∗ |
| T3 liver (pmol/g) | 6.07 (1.01) | 6.82 (1.06) | 8.86 (2.58) |
| T4 serum (nmol/l) | 62.00 (4.04) | 52.33 (3.73) | 72.43 (3.09)∗∗ |
| T3 serum (nmol/l) | 1.63 (0.05) | 1.68 (0.15) | 1.56 (0.10) |
| Thrb mRNA | 2.74 (0.55) | 1.13 (0.10) | 2.15 (0.31)∗ |
| Mct8 mRNA | 3.67 (1.19) | 3.15 (1.41) | 4.36 (1.07) |
| Mct10 mRNA | 1.23 (0.18) | 0.64 (0.09) | 1.20 (0.41) |