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. 2021 Jun 14;22(2):875. doi: 10.3892/etm.2021.10307

Figure 2.

Figure 2

Curcumin inhibits cell viability, migration, and invasion by upregulating miR-301a-3p. (A) Validation of miR-301a-3p expression in THCA using starBase. (B) The expression of miR-301a-3p was determined by real-time quantitative PCR. ***P<0.001, vs. Nthy-ori3-1 cells. (C and D) The expression of miR-301a-3p was determined by real-time quantitative PCR. (E) Cell viability was examined by CCK-8 assay. (F) Cell migration was determined by Transwell cell migration assays and analyzed at a magnification of x20. (G) Cell invasion was determined by Transwell cell invasion assays and analyzed at a magnification of x20. (H) Percentange (%) of wound closure in wound healing assays was analyzed at a magnification of x20. The data are expressed as the mean ± SD. *P<0.05 and ***P<0.001, vs. NC; ##P<0.01 and ###P<0.001, vs. CUR. miR, microRNA; THCA, thyroid carcinoma; NC, negative control; inhibitors, miR-301a-3p inhibitors; CUR, curcumin (23.31 µM).