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. 2021 Jun 14;22(2):875. doi: 10.3892/etm.2021.10307

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Copyright: © Liang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Curcumin inhibits MMP-2, MMP-9 and EMT, and suppresses the JAK/STAT pathway by regulating the miR-301a-3p/STAT3 axis. (A) The expression of MMP-2 and MMP-9 was determined by western blotting. (B) The expression of EMT-related markers was determined by western blot analysis. (C) The levels of phosphorylated and total protein components of the JAK/STAT signaling pathway were determined by western blotting. The data are expressed as the mean ± SD. ^***P<0.01, vs. NC; ^#P<0.05, ^##P<0.01 and ^###P<0.001, vs. CUR. EMT, epithelial-mesenchymal transition; JAK/STAT, Janus kinase/signal transducer and activator of transcription; miR, microRNA; NC, negative control; CUR, curcumin (23.31 µM); mimics, miR-301a-3p mimics; pc-STAT3, overexpression of STAT3.