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. 2021 Jun 27;17:60. doi: 10.1186/s13223-021-00550-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Conceptual model of HRQoL-related themes identified from interviews of 14 patients with HAE-C1INH using C1INH(SC) replacement therapy. The model included concepts which were identified by 5 or more patients during the interviews. Each box represents a theme; bulleted items are concepts. N values are number of patient interviews in which concept was mentioned. The conceptual model concluded that the themes of improved HAE symptoms and lessened impact of HAE attack triggers (center circle) impacted improvements in other themes. AE-QoL Angioedema Quality of Life, ER emergency room, HAE hereditary angioedema, HCP health care practitioner, HRQoL health-related quality of life, C1INH C1 inhibitor, C1INH(SC) subcutaneous C1INH. ^aConcept included even though it was mentioned in less than n = 5 patient interviews because it relates to an item in the AE-QOL