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. Author manuscript; available in PMC: 2021 Jun 28.
Published in final edited form as: Cell Rep. 2020 May 19;31(7):107658. doi: 10.1016/j.celrep.2020.107658

Figure 6. Enrichment of Remyelination-Associated Pathways in Cuprizone-Exposed hGPCs.

Figure 6.

(A) The significantly enriched functional categories highlighted in Figure 5C are organized here by color-defined modules. Enrichment was determined by Fisher’s exact test in Ingenuity Pathway Analysis.

(B) Genes differentially expressed by CZN-exposed hGPCs relative to controls, which contributed to these differentially enriched pathways. Genes upregulated after cuprizone exposure are in red and those downregulated in blue. Activation Z scores are also provided for those pathways for which collective gene expression implies activation (red) or inhibition (blue), following CZN exposure in post-CZN versus CTR hGPCs. Activation Z scores >1 were deemed significant.