Table 2.
Distribution of uncorrected and specific gravity-corrected metabolite concentrations of phthalates and DINCH [ng/mL] in 656 urine samples collected from 205 pregnancies.
| Parent | Metabolite | LOD [ng/mL] |
% detect |
Uncorrected |
SG-corrected |
||||
|---|---|---|---|---|---|---|---|---|---|
| Percentiles |
Percentiles |
||||||||
| 5th | 50th | 95th | 5th | 50th | 95th | ||||
| DEP | MEP | 1.2 | 100 | 4.4 | 23.1 | 223.2 | 5.7 | 23.7 | 194.1 |
| DiBP | MiBP | 0.8 | 98 | 1.5 | 7.2 | 31.2 | 2.1 | 7.4 | 25.0 |
| MHiBP | 0.4 | 97 | 0.6 | 2.6 | 11.0 | 0.8 | 2.6 | 9.3 | |
| DBP | MBP a | 0.4 | 99 | 2.4 | 12.6 | 49.5 | 3.5 | 12.6 | 41.2 |
| MHBP | 0.4 | 82 | <LOD | 1.1 | 4.5 | <LOD | 1.1 | 3.7 | |
| BBzP | MBzP | 0.3 | 99 | 0.8 | 6.4 | 39.6 | 1.2 | 6.4 | 33.6 |
| DEHP | MEHP | 0.8 | 83 | <LOD | 2.6 | 26.1 | <LOD | 2.6 | 28.0 |
| MEHHP | 0.4 | 100 | 1.8 | 12.1 | 136.2 | 2.6 | 11.5 | 107.3 | |
| MEOHP | 0.2 | 100 | 1.5 | 9.3 | 88.5 | 2.2 | 9.3 | 80.2 | |
| MECPP | 0.4 | 100 | 4.0 | 19.2 | 158.4 | 5.6 | 18.4 | 162.9 | |
| DOP, others | MCPP b | 0.4 | 92 | <LOD | 1.8 | 14.9 | <LOD | 1.7 | 13.4 |
| DiNP | MNP | 0.9 | 50 | <LOD | 0.9 | 9.4 | <LOD | 0.9 | 8.3 |
| MCOP | 0.3 | 100 | 2.1 | 13.4 | 175.2 | 3.0 | 13.3 | 149.9 | |
| DiDP | MCNP c | 0.2 | 100 | 0.6 | 2.8 | 26.4 | 0.9 | 2.7 | 25.0 |
| DINCH | MHiNCH | 0.4 | 5.3 | <LOD | <LOD | 0.94 | <LOD | <LOD | 1.37 |
| MCOCH | 0.5 | 19.8 | <LOD | <LOD | 0.48 | <LOD | <LOD | 0.73 | |
MBP is also a minor metabolite of BBzP.
MCPP is also a minor metabolite of DBP and a non-specific metabolite of several high molecular weight phthalates, including DBP, DiNP, DiDP, and di-n-pentyl phthalate (DnPeP).
MCNP is also a minor metabolite of di-2-propylheptyl phthalate (DPHP).
Abbreviation: limit of detection (LOD), diethyl phthalate (DEP), di-isobutyl phthalate (DiBP), dibutyl phthalate (DBP), benzyl butyl phthalate (BBzP), di(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DOP), di-isononyl phthalate (DiNP), di-isodecyl phthalate (DiDP), di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH), monoethyl phthalate (MEP), monoisobutyl phthalate (MiBP), monohydroxyisobutyl phthalate (MHiBP), mono-n-butyl phthalate (MBP), monohydroxybutyl phthalate (MHBP), monobenzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP), mono-3-carboxypropyl phthalate (MCPP), mono-isononyl phthalate (MNP), mono-carboxyisooctyl phthalate (MCOP), mono-carboxyisononyl phthalate (MCNP), cyclohexane-1,2-dicarboxylic acid, and monohydroxy isononyl ester (MHiNCH), and cyclohexane-1,2-dicarboxylic acid, monocarboxy isooctyl ester (MCOCH).