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. Author manuscript; available in PMC: 2022 Jan 4.
Published in final edited form as: Mol Pharm. 2020 Dec 16;18(1):403–415. doi: 10.1021/acs.molpharmaceut.0c01013

Table 2.

Rank normalized score comparisons (Friedman (pairwise comparison) (A) or Kruskal-Wallis test (Independent comparison) (B) with Dunn’s multiple comparisons follow up tests).

A.
Rank Normalized Score: Pairwise Comparison (Adjusted P-score)
Algorithm Ada Bnb DL Knn RF SVC AC
Ada N/A >0.9999 (ns) <0.0001**** <0.0001**** <0.0001**** <0.0001**** <0.0001****
Bnb >0.9999 (ns) N/A <0.0001**** <0.0001**** <0.0001**** <0.0001**** <0.0001****
DL <0.0001**** <0.0001**** N/A <0.0001**** <0.0001**** <0.0001**** <0.0001****
Knn <0.0001**** <0.0001**** <0.0001**** N/A 0.0001*** <0.0001**** <0.0001****
RF <0.0001**** <0.0001**** <0.0001**** 0.0001*** N/A <0.0001**** <0.0001****
SVC <0.0001**** <0.0001**** <0.0001**** <0.0001**** <0.0001**** N/A >0.9999 (ns)
AC <0.0001**** <0.0001**** <0.0001**** <0.0001**** <0.0001**** >0.9999 (ns) N/A
Rank Normalized Score: Pairwise Comparison (Mean Rank Difference)
Winning
Algorithm 		Ada Bnb DL Knn RF SVC AC
Ada N/A 198.5 (ns)
Bnb N/A
DL 7585**** 7784**** N/A
Knn 9776**** 9975**** 2191**** N/A
RF 10763**** 10961**** 3178**** 986.5*** N/A
SVC 16820**** 17019**** 9235**** 7044**** 6058**** N/A
AC 17226**** 17425**** 9641**** 7450**** 6464**** 406 (ns) N/A
B.
Rank Normalized Score: Independent Comparison (Adjusted P-score)
Algorithm Ada Bnb DL Knn RF SVC AC
Ada N/A 0.0011** <0.0001**** <0.0001**** <0.0001**** <0.0001**** <0.0001****
Bnb 0.0011** N/A <0.0001**** <0.0001**** <0.0001**** <0.0001**** <0.0001****
DL <0.0001**** <0.0001**** N/A <0.0001**** <0.0001**** <0.0001**** <0.0001****
Knn <0.0001**** <0.0001**** <0.0001**** N/A >0.9999 (ns) <0.0001**** <0.0001****
RF <0.0001**** <0.0001**** <0.0001**** >0.9999 (ns) N/A <0.0001**** <0.0001****
SVC <0.0001**** <0.0001**** <0.0001**** <0.0001**** <0.0001**** N/A 0.6123 (ns)
AC <0.0001**** <0.0001**** <0.0001**** <0.0001**** <0.0001**** 0.6123 (ns) N/A
Rank Normalized Score: Independent Comparison (Mean Rank Difference)
Winning
Algorithm 		Ada Bnb DL Knn RF SVC AC
Ada N/A 825.8**
Bnb N/A
DL 1996**** 2822**** N/A
Knn 3143**** 3968**** 1146**** N/A
RF 3390**** 4216**** 1394**** 247.4 (ns) N/A
SVC 5008**** 5834**** 3011**** 1865**** 1618**** N/A
AC 5453**** 6278**** 3456**** 2310**** 2062**** 444.8 (ns) N/A

AC = Assay Central (Bayesian), rf = Random Forest, knn = k-Nearest Neighbors, svc = Support Vector Classification, bnb = Naïve Bayesian, ada = AdaBoosted Decision Trees, DL = Deep Learning.