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. 2021 Jun 17;118(25):e2106393118. doi: 10.1073/pnas.2106393118

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Fig. 5. — Rtt105-mediated regulation of RPA promotes high-fidelity replication and recombination while suppressing deleterious repair pathways. (A) ChIP analysis of Rfa1-3xFLAG recruitment at 1 kb location 4 h after DSB induction in indicated strains. (B) Survival rates of DSB repair by ectopic recombination for indicated strains. (C) DNA damage sensitivity test for indicated strains at indicated drug concentrations. (D) Plot showing mutation rates for indicated strains. (E) Graph showing the ratio of each category of mutation in CanR colonies derived from indicated strains. The number of CanR colonies sequenced for each strain is indicated. (F and G) Proportion of multiple-base deletion or duplication in observed mutation events in indicated strains. (H) A diagram showing the SSA assay between two partial leu2 gene repeats separated by 25 kb. (I) Survival rates of DSB repair by SSA in indicated strains. (J) The rate of DSB repair by alt-EJ in indicated cells. The error bar denotes the SD from at least three independent experiments. **P < 0.01.