Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
AMPK-SIRT1-autophagy signaling pathway. Adenosine monophosphate phosphorylates GAPDH which in turn translocates to the nuclei, activates Sirt1 through direct interaction allowing LC3 and histone deacetylation, Brd4 release, recruitment of the methyltransferase G9a and induction of autophagy. Ac, acetylation; P, phosphorylation; Me, methylation.
