FIGURE 3.

mTOR regulates autophagy via targeting acetyltransferases. mTOR can enhance activity of acetyltransferases including p300, GCN5, and hMOF. Phosphorylation of p300 directly acetylates several important autophagy-related proteins and inhibits their function; GNC5 acetylates TFEB and inhibits its downstream autophagy and lysosome gene expression; hMOF acetylates histone proteins directly and inhibits autophagy gene expression; mTOR also increase Foxk1 nuclear location, then the Foxk1 recruits Sin3A-HDAC1/2 complex to chromatin and subsequently decreases autophagy gene expression. Ac, acetylation; P, phosphorylation.