TABLE 2.

Epigenetic factors involved in autophagy signaling.

Epigenetic modification	Epigenetic factor	Modification site	Effect on autophagy	Transcription factors involved	References
Involved in AMPK signaling
Histone acetylation	SIRT1	H4K16	+	FOXO1, TFEB	Cantó et al., 2009; Chang et al., 2015; Sakamaki et al., 2017
	BRD4		–		Sakamaki et al., 2017
	HDAC4/5	H4K16	–		McGee et al., 2008; Chen et al., 2015
	p300		–		Yang et al., 2001; Zhang et al., 2011
	HAT1	H5K5/K12	+		Marin et al., 2017
Histone methylation	EZH2	H3K27	–		Wan et al., 2018
	G9a	H3K9	–		Artal-Martinez de Narvajas et al., 2013; Li et al., 2015; Park et al., 2016; An et al., 2017; Sakamaki et al., 2017
	KDM2A	H3K9	–		Tanaka et al., 2015; Wang et al., 2017
	CARM1	H3Arg17	+	TFEB	Shin et al., 2016
DNA methylation	DNMT1	H3K27	+		Marin et al., 2017; Yang et al., 2018
Histone phosphorylation	H2B	Ser36	+		Bungard et al., 2010; Marin et al., 2015
Involved in mTORC signaling
Histone acetylation	GCN5	K274/K279	+	TFEB	Laboucarié et al., 2017; Wang et al., 2020
	p300		–		Wan et al., 2017
	hMOF	H4K16	–		Fullgrabe et al., 2013
Histone methylation	EZH2	H3K27	–		Wei et al., 2015

+, promotes autophagy; –, inhibits autophagy.