Table 5.

Clinical outcomes for patients with treatment compliant to NCCS guidelines stratified by the BCLC system

BCLC stage	Compliance status	Median OS (95% CI)	p value	Median PFS (95% CI)	p value
Stage 0/A, N = 135	Non-BCLC compliant BCLC compliant	Median OS not reached Median OS not reached	0.8106	24.87 (14.95, ne) Median PFS not reached	0.5282
Stage B, N = 60	Non-BCLC compliant BCLC compliant	25.10 (14.36, 61.31) 14.60 (11.57, ne)	0.7216	7.20 (4.80, 11.63) 7.03 (3.09, 10.84)	0.9054
Stage C, N = 239	Non-BCLC compliant BCLC compliant	14.16 (10.25, 16.66) 7.39 (5.09, 9.03)	0.0002	6.05 (4.67, 8.48) 3.98 (3.22, 5.06)	0.0286
Stage D, N = 24	Non-BCLC compliant BCLC compliant	3.45 (1.54, 16.79) 2.40 (0.36, 9.07)	0.3000	8.89 (2.00, ne) Median PFS did not reach	0.3681

OS and PFS refers to OS and PFS. ne, not estimable; OS, overall survival; PFS, progression-free survival; BCLC, Barcelona Clinic Liver Cancer; CI, confidence interval; NCCS, National Cancer Centre Singapore. p values are based on Gehan-Breslow-Wilcoxon test.