Table 3.
Univariate and multivariable analysis of RFS in pCCA
| Univariate analysis |
Multivariable analysis |
|||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Demographics | ||||
| Sex (male = 1) | 1.12 (0.62–2.02) | 0.704 | ||
| Age (≤65 years = 1) | 0.89 (0.51–1.56) | 0.691 | ||
| BMI (≤25 kg/m2 = 1) | 1.46 (0.83–2.58) | 0.189 | ||
| PVE (no = 1) | 1.23 (0.70–2.16) | 0.478 | ||
| ASA (I/II = 1) | 1.00 (0.57–1.75) | 0.990 | ||
| Preoperative cholangitis (no = 1) | 1.71 (0.94–3.09) | 0.077 | ||
| EBD (no = 1) | 1.23 (0.60–2.54) | 0.576 | ||
| PBD (no = 1) | 1.12 (0.58–2.14) | 0.741 | ||
| Clinical chemistry | ||||
| Albumin (≤40 g/L = 1) | 0.61 (0.33–1.13) | 0.114 | ||
| AST (≤40 U/L = 1) | 1.49 (0.81–2.74) | 0.200 | ||
| ALT (≤40 U/L = 1) | 1.00 (0.46–2.17) | 0.997 | ||
| GGT (≤400 U/L = 1) | 1.25 (0.69–2.28) | 0.463 | ||
| Bilirubin (≤1 mg/dL = 1) | 1.26 (0.72–2.23) | 0.423 | ||
| Alkaline phosphatase (≤250 U/L = 1) | 0.96 (0.53–1.75) | 0.901 | ||
| Platelet count (≤300/nL = 1) | 1.26 (0.68–2.31) | 0.464 | ||
| INR (≤1 = 1) | 1.75 (0.94–3.27) | 0.077 | ||
| Hemoglobin (≤13 g/dL = 1) | 0.56 (0.30–1.05) | 0.069 | ||
| CRP, mg/L (≤10 mg/L = 1) | 1.34 (0.74–2.43) | 0.343 | ||
| Operative data | ||||
| Operative time (≤360 min = 1) | 1.67 (0.85–3.27) | 0.136 | ||
| Type of hepatectomy | ||||
| Right-sided hepatectomy | 1 | 0.466 | ||
| Left-sided hepatectomy | 0.81 (0.45–1.44) | |||
| Blood transfusion (no = 1) | 1.84 (1.05–3.24) | 0.034 | Excluded | |
| FFP transfusion (no = 1) | 2.33 (1.23–4.40) | 0.009 | 3.10 (1.42–6.30) | 0.002 |
| Arterial resection (no = 1) | 0.88 (0.21–3.67) | 0.862 | ||
| Pathological data | ||||
| R1 resection (no = 1) | 2.69 (1.33–5.44) | 0.006 | Excluded | |
| pT category (T1/T2 = 1) | 1.64 (0.92–2.94) | 0.095 | ||
| pN category (N0 = 1) | 2.33 (1.32–4.10) | 0.003 | 2.92 (1.55–5.48) | 0.001 |
| Tumor grading (G1/G2 = 1) | 3.51 (1.82–6.76) | 0.001 | Excluded | |
| MVI (no = 1) | 2.27 (1.23–4.19) | 0.008 | 1.98 (1.01–3.89) | 0.048 |
| LVI (no = 1) | 2.13 (1.11–4.08) | 0.022 | Excluded | |
| PNI (no = 1) | 2.41 (0.86–6.80) | 0.096 | ||
| NFD (low = 1) | 0.35 (0.16–0.75) | 0.007 | 0.42 (0.19–0.93) | 0.031 |
| Oncological data | ||||
| Neoadjuvant therapy (no = 1) | 0.49 (0.07–3.55) | 0.479 | ||
| Adjuvant therapy (yes = 1) | 0.50 (0.27–0.93) | 0.028 | Excluded | |
Various parameters are associated with disease-free survival. Bold numbers indicate statistical significance (p < 0.05). RFS, recurrence-free survival; pCCA, perihilar cholangiocarcinoma; ALT, alanine aminotransferase; ASA, American Society of Anesthesiologists classification; AST, aspartate aminotransferase; CCI, comprehensive complication index; CRP, C-reactive protein; EBD, endoscopic biliary drainage; FFP, fresh frozen plasma; GGT, gamma glutamyltransferase; INR, international normalized ratio; LVI, lymphovascular invasion; MVI, microvascular invasion; NFD, nerve fiber density; PBD, percutaneous biliary drainage; PNI, perineural invasion; PVE, portal vein embolization.