Table 1.
Endocrine toxicity and baseline characteristics
| Overall (N = 551) | No endocrine toxicity (N = 453) | Endocrine toxicity (N = 98) | |||||
|---|---|---|---|---|---|---|---|
| Factor | N | Statistics | N | Statistics | N | Statistics | P-value |
| Age | 551 | 67.4 ± 13.3 | 453 | 67.8 ± 13.5 | 98 | 65.7 ± 12.0 | 0.16a |
| Gender | 551 | 453 | 98 | 0.37c | |||
| Male | 359 (65.2) | 299 (66.0) | 60 (61.2) | ||||
| Female | 192 (34.8) | 154 (34.0) | 38 (38.8) | ||||
| BMI | 551 | 26.5 ± 6.1 | 453 | 26.4 ± 5.9 | 98 | 27.4 ± 6.9 | 0.15b |
| Race | 547 | 450 | 97 | 0.086c | |||
| White | 493 (90.1) | 402 (89.3) | 91 (93.8) | ||||
| Black | 31 (5.7) | 30 (6.7) | 1 (1.03) | ||||
| Other | 23 (4.2) | 18 (4.0) | 5 (5.2) | ||||
| Cancer type treated | |||||||
| Breast | 551 | 8 (1.5) | 453 | 6 (1.3) | 98 | 2 (2.0) | 0.64d |
| Prostate | 551 | 0(0.00) | 453 | 0(0.00) | 98 | 0(0.00) | N/A |
| Bladder | 551 | 47 (8.5) | 453 | 37 (8.2) | 98 | 10 (10.2) | 0.51c |
| Renal cell carcinoma | 551 | 68 (12.3) | 453 | 54 (11.9) | 98 | 14 (14.3) | 0.52c |
| Colon | 551 | 2 (0.36) | 453 | 2 (0.44) | 98 | 0 (0.00) | 0.99d |
| Pancreatic | 551 | 0(0.00) | 453 | 0(0.00) | 98 | 0(0.00) | N/A |
| Esophageal | 551 | 2 (0.36) | 453 | 2 (0.44) | 98 | 0 (0.00) | 0.99d |
| Gastric | 551 | 0(0.00) | 453 | 0(0.00) | 98 | 0(0.00) | N/A |
| Brain | 551 | 4 (0.73) | 453 | 4 (0.88) | 98 | 0 (0.00) | 0.99d |
| Melanoma | 551 | 96 (17.4) | 453 | 66 (14.6) | 98 | 30 (30.6) | <0.001 c |
| Small cell lung cancer | 551 | 18 (3.3) | 453 | 17 (3.8) | 98 | 1 (1.02) | 0.22d |
| Nonsmall cell lung cancer | 551 | 246 (44.6) | 453 | 212 (46.8) | 98 | 34 (34.7) | 0.029 c |
| Sarcoma | 551 | 0(0.00) | 453 | 0(0.00) | 98 | 0(0.00) | N/A |
| Thyroid cancer | 551 | 0(0.00) | 453 | 0(0.00) | 98 | 0(0.00) | N/A |
| Testicular | 551 | 1 (0.18) | 453 | 1 (0.22) | 98 | 0 (0.00) | 0.99d |
| Others (detail) | 551 | 27 (4.9) | 453 | 24 (5.3) | 98 | 3 (3.1) | 0.45d |
| Lymphoma | 551 | 18 (3.3) | 453 | 16 (3.5) | 98 | 2 (2.0) | 0.75d |
| Leukemia | 551 | 1 (0.18) | 453 | 0 (0.00) | 98 | 1 (1.02) | 0.18d |
| Ovarian | 551 | 9 (1.6) | 453 | 8 (1.8) | 98 | 1 (1.02) | 0.99d |
| Oropharyngeal carcinoma | 551 | 10 (1.8) | 453 | 9 (2.0) | 98 | 1 (1.02) | 0.99d |
Statistics presented as mean ± SD or N (%).
Abbreviations: BMI, body mass index; N/A, not applicable.
a t-test.
bSatterthwaite t-test.
cPearson’s chi-square test.
dFisher’s exact test.